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研究業績
●原著論文
2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014
2013 2012以前
●総説
●著書
●解説
原著論文
| 2024 |
| Yukio Tachikawa, Miki Okuno, Takehiko Itoh, Takashi Hirasawa (2024) Metabolic engineering with adaptive laboratory evolution for phenylalanine production by Corynebacterium glutamicum. Journal of Bioscience and Bioengineering 137: 344-353. [Pubmed]
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| 2023 |
| Masato Sone, Kantawat Navanopparatsakul, Shunsuke Takahashi, Chikara Furusawa, Takashi Hirasawa (2023) Loss of function of Hog1 improves glycerol assimilation in Saccharomyces cerevisiae. World Journal of Microbiology and Biotechnology 39:255. [Pubmed]
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| Takashi Hirasawa, Yuki Shimoyamada, Yukio Tachikawa, Yasuharu Satoh, Yusuke Kawano, Tohru Dairi, Iwao Ohtsu (2023) Ergothioneine production by Corynebacterium glutamicum harboring heterologous biosynthesis pathways. Journal of Bioscience and Bioengineering 135:25-33. [Pubmed]
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| 2022 |
| Junya Yamamoto, Onuma Chumsakul, Yoshihiro Toya, Takuya Morimoto, Shenghao Liu, Kenta Masuda, Yasushi Kageyama, Takashi Hirasawa, Fumio Matsuda, Naotake Ogasawara, Hiroshi Shimizu, Ken-ichi Yoshida, Taku Oshima, Shu Ishikawa (2022) Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced Bacillus subtilis strain and improves its metabolite production. DNA Research 29:dsac015. [Pubmed]
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| Dita Grinanda, Takashi Hirasawa (2022) Effectiveness of the Bacillus subtilis genome-reduced strain as an ethanol production host. Bioscience, Biotechnology, and Biochemistry 86:543-551. [Pubmed]
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| 2021 |
Taiji Yuzawa, Tomokazu Shirai, Ryoko Orishimo, Kazuki Kawai, Akihiko Kondo, Takashi Hirasawa (2021) 13C-Metabolic flux analysis in glycerol-assimilating strains of Saccharomyces cerevisiae. Journal of General and Applied Microbiology 67:142-149. [Pubmed]
Covers (Our lab provided images related to this paper):
High resolution images: Top cover Back cover
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| Shunsuke Ogata, Takashi Hirasawa (2021) Induction of glutamic acid production by copper in Corynebacterium glutamicum. Applied Microbiology and Biotechnology 105:6909-6920. [Pubmed]
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| Yutaro Kumagai, Takashi Hirasawa, Masaaki Wachi (2021) Requirement of the LtsA protein for formation of the mycolic acid-containing layer on the cell surface of Corynebacterium glutamicum. Microorganisms 9:409. [Pubmed]
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| 2020 |
| Mia Fitria Utami, Yoshihiko Matsuda, Ayako Takada, Noritaka Iwai, Takashi Hirasawa, Masaaki Wachi (2020) Growth promotion in Corynebacterium glutamicum by overexpression of the NCgl2986 gene encoding a protein homologous to peptidoglycan amidasess. Journal of General and Applied Microbiology 66:1-7. [Pubmed]
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| 2019 |
| Mayumi Kishino, Mariko Kondoh, Takashi Hirasawa (2019) Enhanced L-cysteine production by overexpressing potential L-cysteine exporter genes in an L-cysteine-producing recombinant strain of Corynebacterium glutamicum. Bioscience, Biotechnology, and Biochemistry 83:2390-2393. [Pubmed]
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| Kazuki Kawai, Yu Kanesaki, Hirofumi Yoshikawa, Takashi Hirasawa (2019) Identification of metabolic engineering targets for improving glycerol assimilation ability in Saccharomyces cerevisiae based on adaptive laboratory evolution and transcriptome analysis. Journal of Bioscience and Bioengineering 128:162-169. [Pubmed]
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| Mariko Kondoh, Takashi Hirasawa (2019) L-Cysteine production by metabolically engineered Corynebacterium glutamicum. Applied Microbiology and Biotechnology 103:2609-2619. [Pubmed]
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| 2018 |
| Takashi Hirasawa, Masaki Saito, Katsunori Yoshikawa, Chikara Furusawa, Hiroshi Shimizu (2018) Integrated analysis of the transcriptome and metabolome of Corynebacterium glutamicum during penicillin-induced glutamic acid production. Biotechnology Journal 13:e1700612. [PubMed]
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| 2016 |
| Yuta Matsushima, Takashi Hirasawa, Hiroshi Shimizu (2016) Enhancement of 1,5-diaminopentane production in a recombinant strain of Corynebacterium glutamicum by Tween 40 addition. Journal of General and Applied Microbiology 62:42-45. [PubMed]
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| 2015 |
| Takaaki Horinouchi, Shingo Suzuki, Takashi Hirasawa, Naoaki Ono, Tetsuya Yomo, Hiroshi Shimizu, Chikara Furusawa (2015) Phenotypic convergence in bacterial adaptive evolution to ethanol stress. BMC Evolutionary Biology 15:180. [PubMed]
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| Yoshohiro Toya, Takashi Hirasawa, Shu Ishikawa, Onuma Chumsakul, Takuya Morimoto, Shenghao Liu, Kenta Masuda, Yasushi Kageyama, Katsuya Ozaki, Naotake Ogasawara, Hiroshi Shimizu (2015) Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis. Bioscience, Biotechnology, and Biochemistry 79:2073-2080. [PubMed]
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| Katsunori Yoshikawa, Takashi Hirasawa, Hiroshi Shimizu (2015) Effect of malic enzyme on ethanol production by Synechocystis sp. PCC 6803. Journal of Bioscience and Bioengineering 119:82-84. [Pubmed]
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| 2014 |
| Makoto Uchida, Takashi Hirasawa, Masaaki Wachi (2014) Characterization of a Corynebacterium glutamicum dnaB mutant that shows temperature-sensitive growth and mini-cell formation. Archives of Microbiology 196:871-879. [Pubmed]
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| Tsubasa Nakajima, Shuichi Kajihata, Katsunori Yoshikawa, Fumio Matsuda, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2014) Integrated metabolic flux and omics analysis of Synechocystis sp. PCC 6803 under mixotrophic and photoheterotrophic conditions. Plant and Cell Physiology 55:1605-1612. [Pubmed]
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| Yuto Yamauchi, Takashi Hirasawa, Masato Nishii, Chikara Furusawa, Hiroshi Shimizu (2014) Enhanced acetic acid and succinic acid production under microaerobic conditions by Corynebacterium glutamicum harboring Escherichia coli transhydrogenase gene pntAB. Journal of General and Applied Microbiology 60:112-118. [Pubmed]
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| Kento Tokuyama, Satoshi Ohno, Katsunori Yoshikawa, Takashi Hirasawa, Shotaro Tanaka, Chikara Furusawa, Hiroshi Shimizu (2014) Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli. Microbial Cell Factories 13:64. [Pubmed]
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| Yoshihiro Toya, Takashi Hirasawa, Takuya Morimoto, Kenta Masuda, Yasushi Kageyama, Katsuya Ozaki, Naotake Ogasawara, Hiroshi Shimizu (2014) 13C-Metabolic flux analysis in heterologous cellulase production by Bacillus subtilis genome-reduced strain. Journal of Biotechnology 179:42-49. [Pubmed] |
| Takashi Hirasawa, Yoshihiro Ida, Chikara Furusawa, Hiroshi Shimizu (2014) Potential of a Saccharomyces cerevisiae recombinant strain lacking ethanol and glycerol biosynthesis pathways in efficient anaerobic bioproduction. Bioengineered 5:123-128. [Pubmed] |
| Yuma Ito, Takashi Hirasawa, Hiroshi Shimizu (2014) Metabolic engineering of Saccharomyces cerevisiae for improving succinic acid production based on metabolic profiling. Bioscience, Biotechnology, and Biochemistry 78:151-159. [Pubmed] |
| 2013 |
| Takashi Hirasawa, Masakado Takekuni, Katsunori Yoshikawa, Aki Ookubo, Chikara Furusawa, Hiroshi Shimizu (2013) Genome-wide identification of the targets for genetic manipulation to improve L-lactate production by Saccharomyces cerevisiae by using a single-gene deletion strain collection. Journal of Biotechnology 168:185-193. [Pubmed] |
| Katsunori Yoshikawa, Takashi Hirasawa, Kenichi Ogawa, Yuki Hidaka, Tsubasa Nakajima, Chikara Furusawa, Hiroshi Shimizu (2013) Integrated transcriptomic and metabolomic analysis of the central metabolism of Synechocystis sp. PCC 6803 under different trophic conditions. Biotechnology Journal 8:571-580. [Pubmed] |
| Yoshihiro Ida, Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2013) Utilization of Saccharomyces cerevisiae recombinant strain incapable of both ethanol and glycerol biosynthesis for anaerobic bioproduction. Applied Microbiology and Biotechnology 97:4811-4819. [Pubmed] |
| 2012年以前 |
| Yuki Usui, Takashi Hirasawa, Chikara Furusawa, Tomokazu Shirai, Natsuko Yamamoto, Hirotada Mori, Hiroshi Shimizu (2012) Investigating the effects of perturbations to pgi and eno gene expression on central carbon metabolism in Escherichia coli using 13C metabolic flux analysis. Microbial Cell Factories 11:87. [Pubmed] |
| Siraje Arif Mahmud, Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2012) Understanding the mechanism of heat stress tolerance caused by high trehalose accumulation in Saccharomyces cerevisiae using DNA microarray. Journal of Bioscience and Bioengineering 113:526-528. [Pubmed] |
| Yoshihiro Ida, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2012) Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae. Journal of Bioscience and Bioengineering 113:192-195. [Pubmed] |
| Motoki Umakoshi, Takashi Hirasawa, Chikara Furusawa, Yasuhiro Takenaka, Yoshimi Kikuchi, Hiroshi Shimizu (2011) Improving protein secretion of a transglutaminase-secreting Corynebacterium glutamicum recombinant strain on the basis of 13C metabolic flux analysis. Journal of Bioscience and Bioengineering 112:595-601. [Pubmed] |
| Katsunori Yoshikawa, Yuta Kojima, Tsubasa Nakajima, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2011) Reconstruction and verification of a genome-scale metabolic model for Synechocystis sp. PCC6803. Applied Microbiology and Biotechnology 92:347-358. [Pubmed] |
| Jongpill Kim, Takashi Hirasawa, Masaki Saito, Chikara Furusawa, Hiroshi Shimizu (2011) Investigation of phosphorylation status of OdhI protein during penicillin- and Tween 40-triggered glutamate overproduction by Corynebacterium glutamicum. Applied Microbiology and Biotechnology 91:143-151. [Pubmed] |
| Katsunori Yoshikawa, Tadamasa Tanaka, Yoshihiro Ida, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2011) Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae. Yeast 28:349-361. [Pubmed] |
| Takaaki Horinouchi, Kuniyasu Tamaoka, Chikara Furusawa, Naoaki Ono, Shingo Suzuki, Takashi Hirasawa, Tetsuya Yomo, Hiroshi Shimizu (2010) Transcriptome analysis of parallel-evolved Escherichia coli strains under ethanol stress. BMC Genomics 11:579. [Pubmed] |
| Takaaki Horinouchi, Katsunori Yoshikawa, Risa Kawaide, Chikara Furusawa, Yoshihiro Nakao, Takashi Hirasawa, Hiroshi Shimizu (2010) Genome-wide expression analysis of Saccharomyces pastorianus orthologous genes using oligonucleotide microarrays. Journal of Bioscience and Bioengineering 110:602-607. [Pubmed] |
| Yoshihiro Toya, Nobuyoshi Ishii, Kenji Nakahigashi, Takashi Hirasawa, Tomoyoshi Soga, Masaru Tomita, Kazuyuki Shimizu (2010) 13C-Metabolic flux analysis for batch culture of Escherichia coli and its pyk and pgi gene knockout mutants based on mass isotopomer distribution of intracellular metabolites. Biotechnology Progress 26:975-992. [Pubmed] |
| Jongpill Kim, Hirohisa Fukuda, Takashi Hirasawa, Keisuke Nagahisa, Kazuo Nagai, Masaaki Wachi, Hiroshi Shimizu (2010) Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum. Applied Microbiology and Biotechnology 86:911-920. [Pubmed] |
| Siraje Arif Mahmud, Takashi Hirasawa, Hiroshi Shimizu (2010) Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses. Journal of Bioscience and Bioengineering 109:262-266. [Pubmed] |
| Tadashi Yamada, Jianhong Ou, Chikara Furusawa, Takashi Hirasawa, Tetsuya Yomo, Hiroshi Shimizu (2010) Relationship between noise characteristics in protein expressions and regulatory structures of amino acid biosynthesis pathways. IET Systems Biology 4:82-89. [Pubmed] |
| Takashi Hirasawa, Aki Ookubo, Katsunori Yoshikawa, Keisuke Nagahisa, Chikara Furusawa, Hideki Sawai, Hiroshi Shimizu (2009) Investigating the effectiveness of DNA microarray analysis for identifying the genes involved in L-lactate production by Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 84:1149-1159. [Pubmed] |
| Thai Nho Dinh, Keisuke Nagahisa, Katsunori Yoshikawa, Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2009) Analysis of adaptation to high ethanol concentration in Saccharomyces cerevisiae using DNA microarray. Bioprocess and Biosystems Engineering 32:681-688. [Pubmed] |
| Yohei Shinfuku, Natee Sorpitiporn, Masahiro Sono, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2009) Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum. Microbial Cell Factories 8:43. [Pubmed] |
| Takashi Hirasawa, Kazuyuki Yamada, Keisuke Nagahisa, Thai Nho Dinh, Chikara Furusawa, Yoshio Katakura, Suteaki Shioya, Hiroshi Shimizu (2009) Proteomic analysis of responses to osmotic stress in laboratory and sake-brewing strains of Saccharomyces cerevisiae. Process Biochemistry 44:647-653. |
| Katsunori Yoshikawa, Tadamasa Tanaka, Chikara Furusawa, Keisuke Nagahisa, Takashi Hirasawa, Hiroshi Shimizu (2009) Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. FEMS Yeast Research 9:32-44. |
| Siraje Arif Mahmud, Keisuke Nagahisa, Takashi Hirasawa, Katsunori Yoshikawa, Kengo Ashitani, Hiroshi Shimizu (2009) Effect of trehalose accumulation on response to saline stress in Saccharomyces cerevisiae. Yeast 26:17-30. |
| Jongpill Kim, Takashi Hirasawa, Yoshiyasu Sato, Keisuke Nagahisa, Chikara Furusawa, Hiroshi Shimizu (2009) Effect of odhA overexpression and odhA antisense RNA expression on Tween-40-triggered glutamate production by Corynebacterium glutamicum. Applied Microbiology Biotechnology 81:1097-1106. |
| Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2008) Genome-wide analysis of the effects of location and number of stress response elements on gene expression in Saccharomyces cerevisiae. Journal of Bioscience and Bioengineering 106:507-510. |
| Aki Ookubo, Takashi Hirasawa, Katsunori Yoshikawa, Keisuke Nagahisa, Chikara Furusawa, Hiroshi Shimizu (2008) Improvement of L-lactate production by CYB2 gene disruption in a recombinant Saccharomyces cerevisiae strain under low pH condition. Bioscience, Biotechnology, and Biochemistry 72:3063-3066. |
| Hiroki Sato, Keita Orishimo, Tomokazu Shirai, Takashi Hirasawa, Keisuke Nagahisa, Hiroshi Shimizu, Masaaki Wachi (2008) Distinct roles of two anaplerotic pathways in glutamate production induced by biotin limitation in Corynebacterium glutamicum. Journal of Bioscience and Bioengineering 106:51-58. |
| Thai Nho Dinh, Keisuke Nagahisa, Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2008) Adaptation of Saccharomyces cerevisiae cells to high ethanol concentration and changes in fatty acid composition of membrane and cell size. PLoS One 3:e2623. |
| Jianhong Ou, Tadashi Yamada, Keisuke Nagahisa, Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2008) Dynamic change in promoter activation during lysine biosynthesis in Escherichia coli cell. Molecular BioSystems 4:128-134. |
| Nobuyoshi Ishii#, Kenji Nakahigashi#, Tomoya Baba#, Martin Robert#, Tomoyoshi Soga#, Akio Kanai#, Takashi Hirasawa#, Miki Naba, Kenta Hirai, Aminul Hoque, Pei Yee Ho, Yuji Kakazu, Kaori Sugawara, Saori Igarashi, Satoshi Harada, Takeshi Masuda, Naoyuki Sugiyama, Takashi Togashi, Miki Hasegawa, Yuki Takai, Katsuyuki Yugi, Kazuharu Arakawa, Nayuta Iwata, Yoshihiro Toya, Yoichi Nakayama, Takaaki Nishioka, Kazuyuki Shimizu, Hirotada Mori, Masaru Tomita (2007) Multiple high throughput analyses monitor the response of E. coli to perturbations. Science 316:593-597. (#Equally contributed) |
| Yoshihiro Toya, Nobuyoshi Ishii, Takashi Hirasawa, Miki Naba, Kenta Hirai, Kaori Sugawara, Saori Igarashi, Kazuyuki Shimizu, Masaru Tomita, Tomoyoshi Soga (2007) Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis. Journal of Chromatography A 1159:134-141. |
| Takashi Hirasawa, Katsunori Yoshikawa, Yuki Nakakura, Keisuke Nagahisa, Chikara Furusawa, Yoshio Katakura, Hiroshi Shimizu, Suteaki Shioya (2007) Identification of target genes for conferring ethanol stress-tolerance to yeast Saccharomyces cerevisiae based on DNA microarray data analysis. Journal of Biotechnology 131:33-44. |
| Gaurav Pandey, Katsunori Yoshikawa, Takashi Hirasawa, Keisuke Nagahisa, Yoshio Katakura, Chikara Furusawa, Hiroshi Shimizu, Suteaki Shioya (2007) Extracting hidden features in saline osmotic tolerance in Saccharomyces cerevisiae from DNA microarray data using self-organizing map: biosynthesis of amino acids. Applied Microbiology and Biotechnology 75: 415-426. |
| Takashi Hirasawa, Kengo Ashitani, Katsunori Yoshikawa, Keisuke Nagahisa, Chikara Furusawa, Yoshio Katakura, Hiroshi Shimizu, Suteaki Shioya (2006) Comparison of transcriptional responses to osmotic stresses induced by NaCl and sorbitol additions in Saccharomyces cerevisiae using DNA microarray. Journal of Bioscience and Bioengineering 102:568-571. |
| Takashi Hirasawa, Yuki Nakakura, Katsunori Yoshikawa, Kengo Ashitani, Keisuke Nagahisa, Chikara Furusawa, Yoshio Katakura, Hiroshi Shimizu, Suetaki Shioya (2006) Comparative analysis of transcriptional responses to saline stress in the laboratory and brewing strains of Saccharomyces cerevisiae with DNA microarray. Applied Microbiology and Biotechnology 70:346-357. |
| Yutaro Kumagai, Takashi Hirasawa, Kenshi Hayakawa, Kazuo Nagai, Masaaki Wachi (2005) Fluorescent phospholipid analogs as microscopic probes for detection of the mycolic acid-containing layer in Corynebacterium glutamicum: detecting alterations in the mycolic acid-containing layer following ethambutol treatment. Bioscience, Biotechnology, and Biochemistry 69:2051-2056. |
| Takashi Hirasawa, Yutaro Kumagai, Kazuo Nagai, Masaaki Wachi (2003) A Corynebacterium glutamicum rnhA recG double mutant showing lysozyme-sensitivity, temperature-sensitive growth, and UV-sensitivity. Bioscience, Biotechnology, and Biochemistry 67:2416-2424. |
| H. Fujishima, A. Nishimura, M. Wachi, H. Takagi, T. Hirasawa, H. Teraoka, K. Nishimori, T. Kawabata, K. Nishikawa, K. Nagai (2002) kdsA mutations affect FtsZ-ring formation in Escherichia coli K-12. Microbiology 148:103-112. |
| Takashi Hirasawa, Masaaki Wachi, Kazuo Nagai (2001) L-Glutamate production by lysozyme-sensitive Corynebacterium glutamicum ltsA mutant strains. BMC Biotechnology 1:9. |
| Takashi Hirasawa, Masaaki Wachi, Kazuo Nagai (2000) A mutation in the Corynebacterium glutamicum ltsA gene causes susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production. Journal of Bacteriology 182:2696-2701. |
| Kohji Nagano, Masaaki Wachi, Ayako Takada, Fumie Takaku, Takashi Hirasawa, Kazuo Nagai (1999) fcsA29 mutation is an allele of polA gene of Escherichia coli. Bioscience, Biotechnology, and Biochemistry 63:427-429. |
総説
| Takashi Hirasawa, Tomoya Maeda (2023) Adaptive Laboratory Evolution of Microorganisms: Methodology and Application for Bioproduction. Microorganisms 11:92.
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| Takashi Hirasawa, Hiroshi Shimizu (2016) Recent advances in amino acid production by microbial cells. Current Opinion in Biotechnology 42:133-146. [Pubmed] |
| Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2010) Saccharomyces cerevisiae and DNA microarray analyses: what did we learn from it for a better understanding and exploitation of yeast biotechnology. Applied Microbiology and Biotechnology 87:391-400. |
| Suteaki Shioya, Hiroshi Shimizu, Takashi Hirasawa, Keisuke Nagahisa, Chikara Furusawa, Gaurav Pandey, Yoshii Katakura (2007) Metabolic pathway rerouting through genomic data analysis for industrial application of Saccharomyces cerevisiae. Biochemical Engineering Journal 36:28-37. |
著書
| 平沢 敬（2013）バイオテクノロジーシリーズ 微生物を活用した有用物質の製造技術「第7章 食品素材の生産 1. コリネ型細菌Corynebacterium glutamicumによるアミノ酸の発酵生産：L-グルタミン酸の直接発酵とアミノ酸生産株の育種」 蓮沼誠久監修 シーエムシー出版 |
| Hiroshi Shimizu, Chikara Furusawa, Takashi Hirasawa, Katsunori Yoshikawa, Yoshihiro Toya, Tomokazu Shirai, Fumio Matsuda (2017) Omics-integrated approach for metabolic state analysis of microbial processes. In Applied Bioengineering. Volume 5, Innovations and Future Directions. Toshiomi Yoshida (ed), Wiley. pp. 213-236. |
| Takashi Hirasawa, Masaaki Wachi (2017) Glutamate fermentation-2: mechanism of L-glutamate overproduction in Corynebacterium glutamicum. In Advances in Biochemical Engineering/Biotechnology. Volume 159. Amino Acid Fermentation. Atsushi Yokota and Masato Ikeda (eds), Springer. pp. 57-72. |
| Takashi Hirasawa, Hiroshi Shimizu (2016) Glutamic acid fermentation: Discovery of glutamic acid-producing microorganisms, analysis of the production mechanism, metabolic engineering, and industrial production proces. In Industrial Biotechnology: Products and Processes. Christoph Wittmann and James C. Liao (eds), Wiley. pp. 339-360. |
| Takashi Hirasawa, Hiroshi Shimizu (2014) Glutamic acid. In Bioprocessing of renewable resources to commodity bioproducts. Virendra S. Bisaria and Akihiko Kondo (eds), Wiley. pp. 473-496. |
| Chikara Furusawa, Takaaki Horinouchi, Takashi Hirasawa, Hiroshi Shimizu (2012) Systems metabolic engineering: the creation of microbial cell factories by rational metabolic design and evolution. In Advanced Biochemical Engineering/Biotechnology. Volume 131, Future Trends in Biotechnology. Jian-Jiang Zhong (ed), Springer. pp. 1-23. |
| Takashi Hirasawa, Jongpill Kim, Tomokazu Shirai, Chikara Furusawa, Hiroshi Shimizu (2012) Molecular mechanisms and metabolic engineering of glutamate overproduction in Corynebacterium glutamicum. In Subcellular Biochemistry, Volume 64, Reprogramming Microbial Metabolic Pathways. Xiaoyuan Wang, Jian Chen and Peter J. Quinn (eds), Springer. pp. 261-281. |
| Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu (2012) Design of superior cell factories based on systems wide omics analysis. In Systems Metabolic Engineering. Christoph Wittmann and Sang Yup Lee (eds), Springer. pp. 51-58. |
| 清水 浩、古澤 力、白井智量、吉川勝徳、平沢 敬 (2012) 合成生物工学の隆起-有用物質の新たな生産法構築をめざして- 「第三章 オミクス解析の視点 2. ゲノムスケール代謝デザインとフラックス解析による微生物細胞創製」植田充美監修 シーエムシー出版 |
| 平沢 敬 (2008) ベーシックマスター生化学「第9章 クエン酸回路と電子伝達系」大山 隆監修 西川一八・清水光弘共編 オーム社 |
| Hiroshi Shimizu, Takashi Hirasawa. (2007) Production of glutamate and glutamate-related amino acids: Molecular mechanism analysis and metabolic engineering. In Microbiology Monograph. Volume 5. Amino acid biosynthesis-pathways, regulation and metabolic engineering. Volker F. Wendisch (ed), Springer. pp 1-38. |
| Hiroshi Shimizu, Takashi Hirasawa, Keisuke Nagahisa, Suteaki Shioya (2004) Analysis of responses of complex bionetworks to changes in environmental conditions. In Lecture Note Series of Computer Science. Vol. 3141. Biologically Inspired Approaches to Advanced Information Technology, First International Workshop, BioADIT 2004, Lausanne, Switzerland, January 29-30, 2004, Revised Selected Papers. Auke Jan Ijspeert, Masayuki Murata and Naoki Wakamiya (eds), Springer. pp. 13-27. |
解説
| 平沢 敬 (2022) 銅添加によるコリネ型細菌のグルタミン酸生産誘導 バイオサイエンスとインダストリー 80:250-251. |
| 平沢 敬 (2021) 続・生物工学基礎講座-バイオよもやま話-「コリネ型細菌Corynebacterium glutamicum-グルタミン酸生産の基礎と有用物質生産への応用-」 生物工学会誌 99:29-32. |
| 清水 浩、古澤 力、平沢 敬、吉川勝徳、小野直亮、戸谷吉博、白井智量 (2013) 代謝工学の創成と発展-代謝解析とオミクス研究との融合 生物工学会誌 90:619-620. |
| 吉川勝徳、古澤 力、平沢 敬、清水 浩 光合成微生物システムバイオロジー 生物工学会誌 90:627-628. |
| Siraje Arif Mahmud、平沢 敬、清水 浩 (2012) Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses. 生物工学会誌 90:80. |
| Yohei Shinfuku, Natee Sorpitiporn, Masahiro Sono, Takashi Hirasawa, Chikara Furusawa, Hiroshi Shimizu (2010) Development of a prediction system for metabolic fluxes based on genome information. ソフトウェアバイオロジー 9:18-21. |
| 平沢 敬 (2009) Synthetic biologyの考え方を育種に活用する 生物工学会誌 87:338. |
| 平沢 敬、大久保亜紀、吉川勝徳、古澤 力、清水 浩 (2009) 乳酸生産能を付与した酵母の網羅的遺伝子発現情報に基づいた生産性向上のための育種 ソフトウエアバイオロジー 8:54-61. |
| 清水 浩、古澤 力、平沢 敬 (2008) バイオ情報を基盤とする有用生物創製の時代を拓く代謝情報工学 バイオサイエンスとインダストリー 66:426-432. |
| 平沢 敬 (2008) ゲノムワイドな網羅的解析を用いた有用微生物の創製 生産と技術 60:16-19. |
| 清水 浩、平沢 敬、永久圭介、古澤 力、片倉啓雄、塩谷捨明 (2006) 情報科学を基盤とする有用生物創製にむけて ソフトウェアバイオロジー 5:39-42. |
| Takashi Hirasawa, Yuki Nakakura, Zhao Hui, Keisuke Nagahisa, Chikara Furusawa, Yoshio Katakura, Suteaki Shioya, Hiroshi Shimizu. (2005) Metabolic pathway modification based on DNA microarray data in the yeast Saccharomyces cerevisiae. ソフトウェアバイオロジー 4:16-23. |
| Katsunori Yoshikawa, Gaurav Pandey, Takashi Hirasawa, Yoshio Katakura, Keisuke Nagahisa, Chikara Furusawa, Suteaki Shioya, Hiroshi Shimizu. (2005) DNA microarray analysis with an integrating method of self-organizing map and hierarchical clustering. ソフトウェアバイオロジー 4:12-15. |
| Keisuke Nagahisa, Kazuyuki Yamada, Yuki Nakakura, Takashi Hirasawa, Yoshio Katakura, Suteaki Shioya, Hiroshi Shimizu. (2005) Proteome analysis on adaptation of yeast cells to a high osmotic pressure stress. ソフトウェアバイオロジー 4:7-11. |
| Tomokazu Shirai, Masanori Kuzumoto, Takashi Hirasawa, Yoshio Katakura, Keisuke Nagahisa, Chikara Furusawa, Suteaki Shioya, Hiroshi Shimizu. (2005) Analysis of metabolic flow control in glutamate production by coryneform bacteria. ソフトウェアバイオロジー 4:24-30. |
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